Mouse Anti-S100B Monoclonal Antibody (CBP6782)

Description

Neuroinflammation is locally produced in the central nervous system through phenotypic changes of different non-neuronal cell types (such as microglia, oligodendrocytes, and astrocytes) in the brain, leading to different cytokines and chemokines The release of C, eventually recruits and infiltrates peripheral blood cells, mainly T-and B cells, into the brain parenchyma. S100 calcium binding protein B (S100B) is a protein of the S-100 protein family.S100 protein is located in the cytoplasm and nucleus of a large number of cells and participates in the regulation of many cellular processes, such as cell cycle progression and differentiation. The S100 gene includes at least 13 members clustered on chromosome 1q21. However, the gene is located at 21q22.3.S100B is glial-specific and is mainly expressed by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is expressed only by mature astrocyte subtypes that surround blood vessels and cells expressing NG2. The protein may play a role in neurite outgrowth, melanoma cell proliferation, Ca2+ flux stimulation, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing central nervous system, it acts as a neurotrophic factor and neuronal survival protein. In adult organisms, it is usually elevated due to damage to the nervous system, which makes it a potential clinical marker.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6782

Applications

IHC; WB

Application Notes

IHC: 1:500-1:1000
WB: 1 µg/ml

Marker

Glial Cell Markers; Astrocyte Markers

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

S100 Beta

Official Name

S100B

Full Name

S100 calcium-binding protein B

Alternative Names

S100B; NEF; S100; S100-B; S100beta; S100 calcium binding protein B

Gene ID

6285(Human); 20203(Mouse); 25742(Rat)

Uniprot ID

P04271(Human); P50114(Mouse); P04631(Rat)