Mouse Anti-CHAT Monoclonal Antibody (CBP6808)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. Choline acetyltransferase (ChAT) is an enzyme responsible for Catalyzes the synthesis of acetylcholine and in Most cholinergic neurons. Therefore, ChAT immune response Used to detect cognitive decline in several neurodegenerative diseases obstacle. Choline acetyltransferase (often abbreviated as ChAT, but sometimes also called CAT) is a transferase responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of acetyl groups from the coenzyme acetyl-CoA to choline to produce acetylcholine (ACh). High levels of ChAT are found in cholinergic neurons in the central nervous system (CNS) and peripheral nervous system (PNS). Like most nerve terminal proteins, ChAT is produced in neurons and transported to nerve terminals with the highest concentration. The presence of ChAT in nerve cells classifies the cells as "cholinergic" neurons. In humans, choline acetyltransferase is encoded by the CHAT gene.

Epitope

Binds to an located within the peptide sequence GLFSSYRLPGHTQDT

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6808

Applications

IHC; IF

Application Notes

IHC: 1:1000-1:2500
IF: 2-10 µg/ml

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

Choline Acetyltransferase

Official Name

CHAT

Full Name

Choline Acetyltransferase

Alternative Names

CHAT; CHOACTASE; CMS1A; CMS1A2; CMS6; choline O-acetyltransferase

Gene ID

1103 (Human); 12647 (Mouse); 290567 (Rat)

Uniprot ID

P28329 (Human); Q03059 (Mouse); P32738 (Rat)