Human CHO-K1/ADORA2B/Gα15 Stable Cell Line

[CAT#: NCL20120016CR]

Adenosine A2B Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Request Pricing

Inquiry

Product Overview

Description

ADORA2B is Gs and Gq/11-coupled GPCR expressed in the Large intestine, cecum, urinary bladder. ADORA2B receptor mediates relaxation to adenosine in human small coronary arteries which is independent of NO but dependents in part on a K+-sensitive mechanism. Pharmacological or molecular biologic activation of ADORA2B receptor may prevent glomerular remodeling associated with glomerulosclerosis, renal disease, and abnormal growth associated with hypertension and diabetes.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

ADORA2B

Family

Adenosine receptor

Strain

ADORA2B/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

A2BR

Official Name

A2BR

Full Name

A2B receptor

Alternative Names

A2B receptor; A2b; adenosine A2B receptor; A2b; AA2BR; A2BR; A2BAR

Gene ID

3181(Human); 100045191(Mouse); 362361(Rat)

Uniprot ID

P22626(Human); O88569(Mouse); A7VJC2(Rat)

References

1. Jamal-Livani, N., Mohammadian, E., Arabi, M. S., & Safdari, Y. (2020). Protein-based drug carrier specific for HER2-positive breast cancer cells. Journal of Drug Delivery Science and Technology, 101623. 2. Rebois, R. V., Maki, K., Meeks, J. A., Fishman, P. H., Hébert, T. E., & Northup, J. K. (2012). D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs-and Gi-mediated regulation of adenylyl cyclase. Cellular signalling, 24(11), 2051-2060.

Publications