Human CHO-K1/ADRB1/Gα15 Stable Cell Line

[CAT#: NCL20120023CR]

ADRB1 Adrenoceptors Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The β-adrenergic receptors are linked to G proteins. The β-receptor has three known subtypes. Beta-1 receptors primarily regulate myocardial tissue and affect the rate of contraction via impulse conduction. Beta-2 receptors regulate smooth muscle tone and influence vascular and bronchiolar relaxation. Beta-3 receptors are less well studied but are thought to primarily affect lypolysis and may have effects on cardiac inotropy.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

ADRB1

Family

Adrenoceptors

Strain

ADRB1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

ADRB1R

Official Name

ADRB1R

Alternative Names

B1AR; RATB1AR; ADRB1R; beta 1-adrenoceptor; beta 1-adrenergic receptor; beta 1-AR; beta 1-AR; Adrb-1; adrenergic receptor beta 1

Gene ID

153(Human); 11554(Mouse); 24925(Rat)

Uniprot ID

P08588(Human); P34971(Mouse)

References

1. Yang, E. L., Sun, B., Huang, Z. Y., Lin, J. G., Jiao, B., & Xiang, L. (2019). Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea. Journal of Natural Products, 82(11), 2986-2993.

Publications