Human CHO-K1/CRF1/Gα15 Stable Cell Line

[CAT#: NCL20120051CR]

Corticotropin Releasing Factor Receptor CRF1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The CRF1 receptor is a Gs-coupled GPCR expressed in the brain and pituitary gland that binds to several neuropeptides, including corticotropin-releasing factor (CRF) and urocortin, and the amphibian peptide sauvagine. CRF plays a predominant role in stress response mediated by the hypothalamic-pituitary-adrenal axis, and alterations in CRF and its receptors CRF1 and CRF2 appear to be linked to depression and anxiety. In comparison to the CRF2 receptor, the CRF1 receptor has received considerable attention as a potential therapeutic target for the treatment of stress-related disorders such as adrenocorticotropin hypersecretion, increased colonic motility and exaggerated fear and anxiety-related behavior.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

CRF1/CRHR1

Family

Corticotropin releasing factor receptor

Strain

CRF1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

CRF1

Official Name

CRF1

Alternative Names

CRF1 receptor; CRH1; CRFR1; CRF-R1; CRF-RA; PC-CRF; CRHR; CRF-R; CRF1; corticotropin-releasing factor receptor; CRF-R-1; CRFR-1; CRH-R 1; CRH-R-1; CRH-R1; corticotropin releasing hormone 1; corticotropin releasing hormone receptor 1; corticotropin-releasing factor receptor 1; CRF-R1alpha; CRF 1 receptor