Human CHO-K1/GALR2 Stable Cell Line

[CAT#: NCL20120063CR]

GAL2 Galanin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Actions of neuropeptide galanin are mediated by three G-protein coupled receptors, GalR1, GalR2, and GalR3. Human GALR2 was shown to couple to phospholipase C and to be involved in the elevation of intracellular calcium levels. GALR2 mRNA shows a wide distribution in the brain (mammillary nuclei, dentate gyrus, cingulate gyrus, posterior hypothalamic, supraoptic, and arcuate nuclei) and restricted peripheral tissue distribution with highest mRNA levels detected in human small intestine. Galanin has been implicated in anxiety-related behaviors, cognition, analgesia, and feeding in rodents.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

GALR2

Family

Galanin receptor

Strain

GALR2 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

GALR2

Official Name

GALR2

Alternative Names

GAL2 receptor; Galanin-2 receptor; GALNR2; GAL2-R; GALR-2; galanin receptor 2; galanin receptor type 2; mGalR; gal2

Gene ID

8811(Human); 14428(Mouse); 29234(Rat)

Uniprot ID

O43603(Human); O88854(Mouse); O08726(Rat)

References

1. Hamidi, S. R., Safdari, Y., & Arabi, M. S. (2019). Test bacterial inclusion body for activity prior to start denaturing and refolding processes to obtain active eukaryotic proteins. Protein expression and purification, 154, 147-151. 2. Banisadr, A., Safdari, Y., Kianmehr, A., & Pourafshar, M. (2018). Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR-overexpressing cancer cells. Human vaccines & immunotherapeutics, 14(4), 856-863. 3. Pourafshar, M., Safdari, Y., Khajeniazi, S., Yazdani, Y., Banisadr, A., & Veisi, K. (2018). Production and Characterization of Single Chain Nimotuzumab: An In Vitro Study. International Journal of Peptide Research and Therapeutics, 24(1), 171-178.

Publications