Human CHO-K1/OPRK1/Gα15 Stable Cell Line

[CAT#: NCL20120100CR]

κ-Opioid Receptor OPRK1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Opioid receptors and their endogenous peptide ligands play important roles in the reward and reinforcement of drugs such as heroin, cocaine, and alcohol. The κ-opioid receptor is a type of opioid receptor which binds the peptide opioid dynorphin as the primary endogenous ligand. κ-opioid receptors are widely distributed in the brain, spinal cord, and in pain neurons. They are associated with the risk for alcohol dependence.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

OPRK1

Family

Opioid & opioid-like receptor

Strain

OPRK1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

Kappa Opioid Receptor

Official Name

OPRK1

Alternative Names

KOP; KOR-1; Kappa opioid receptor; OP2; KOR; K-OR-1; kappa-type opioid receptor; opioid receptor; kappa 1; Oprk2; R21; KOP-r

Gene ID

18387(Mouse); 29335(Rat)

Uniprot ID

P33534(Mouse); P34975(Rat)

References

1. Hamidi, S. R., Safdari, Y., & Arabi, M. S. (2019). Test bacterial inclusion body for activity prior to start denaturing and refolding processes to obtain active eukaryotic proteins. Protein expression and purification, 154, 147-151. 2. Banisadr, A., Safdari, Y., Kianmehr, A., & Pourafshar, M. (2018). Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR-overexpressing cancer cells. Human vaccines & immunotherapeutics, 14(4), 856-863. 3. Pourafshar, M., Safdari, Y., Khajeniazi, S., Yazdani, Y., Banisadr, A., & Veisi, K. (2018). Production and Characterization of Single Chain Nimotuzumab: An In Vitro Study. International Journal of Peptide Research and Therapeutics, 24(1), 171-178.

Publications