NeuCELL™ VM Human Neural Progenitor Cell Line, Immortalized

[CAT#: NCL-2108-P002]

NeuCELL™ VM is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons & glial cells.

Species:: Human

Applications:: Cell Culture

Cell Types:: Neural Progenitor Cells

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Product Overview

Description

An immortalised cell line of human neural progenitors called NeuCELL™ VM may easily develop into neurons and glial cells. The ventral mesencephalon of the foetal human brain served as the source of NeuCELL™ VM. The v-myc oncogene was immortalised by retroviral transduction, and this cell line grows quickly as a monolayer on laminin with a doubling period of 20-30 hours. According to karyotype investigations, the NeuCELL™ VM maintains a typical diploid karyotype in culture even after numerous passages (more than 45 passages). Furthermore, it has been demonstrated that neurons derived from NeuCELL™ VM are electophysiologically active. Numerous research projects can make use of NeuCELL™ VM, including investigations into neurotoxicity, neurogenesis, electrophysiology, and the actions of neurotransmitters and receptors.

Cell Types

Neural Progenitor Cells

Applications

Cell Culture

Application Notes

NeuCELL™ can be used in a 3D cell model of Alzheimer's Disease!

Species

Human

Properties

Size

>1x10^6 Cells

Tissue Source

Human ventral mesencephalon brain tissue

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

Each lot of NeuCELL™ cells has been validated for high level of expression of Nestin and Sox 2 and for their self-renewal and multi-lineage differentiation capacities. Cells also display normal karyotype as assessed by chromosome spread and tested negative for mycoplasma. Maternal blood has been screened for HIV, HTLV, Hepatitis B and C.

Publications