NeuroMab™ Anti-Alpha-2C adrenergic receptor BBB Shuttle Antibody, Clone N330A/51
[CAT#: NRZP-0423-ZP12]
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ADRA2C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (also known as Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2CAR, ADRA2C, ADRA2L2 and ADRARL2, accession number P18825)
Mouse: 100% identity (21/21 amino acids identical)
Rat: 100% identity (21/21 amino acids identical)
>70% identity with Alpha-2B adrenergic receptor
Mouse: 100% identity (21/21 amino acids identical)
Rat: 100% identity (21/21 amino acids identical)
>70% identity with Alpha-2B adrenergic receptor
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N330A/51
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with other adrenergic receptors (based on KO validation results)
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ADRA2C
Official Name
ADRA2C
Full Name
Alpha-2C adrenergic receptor
Alternative Names
Alpha-2C adrenoceptor; Alpha 2-C4; adrenergic; alpha-2C; Adrenergic alpha 2C- receptor class I; alpha 2c; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; subtype alpha2-C4; alpha2-C4; alpha2C; [a]2C; Adra-2c
Uniprot ID
P18825
Product Pictures
IB
Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged Alpha-2C and Alpha-2A adrenergic receptor or untagged Kv2.1 plasmid and probed with N330A/51 TC supe.
Publications
Publications (0)
Neural Cell Lines
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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