NeuroMab™ Anti-Alpha-2C adrenergic receptor BBB Shuttle Antibody, Clone N330A/80

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ADRA2C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (also known as Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2CAR, ADRA2C, ADRA2L2 and ADRARL2, accession number P18825)
Mouse: 100% identity (21/21 amino acids identical)
Rat: 100% identity (21/21 amino acids identical)
>70% identity with Alpha-2B adrenergic receptor

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N330A/80

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other adrenergic receptors (based on KO validation results)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ADRA2C

Official Name

ADRA2C

Full Name

Alpha-2C adrenergic receptor

Alternative Names

Alpha-2C adrenoceptor; Alpha 2-C4; adrenergic; alpha-2C; Adrenergic alpha 2C- receptor class I; alpha 2c; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; subtype alpha2-C4; alpha2-C4; alpha2C; [a]2C; Adra-2c

Uniprot ID

P18825

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged Alpha-2C and Alpha-2A adrenergic receptor or untagged Kv2.1 plasmid and probed with N330A/80 TC supe.

Publications