NeuroMab™ Anti-C5aR BBB Shuttle Antibody(NRZP-1022-ZP3170)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; ADCC; CDC; Cyt; Block; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD88

Official Name

C5AR1

Full Name

Complement component 5a receptor 1

Alternative Names

C5AR1; C5A; C5AR; C5R1; CD88; complement component 5a receptor 1; C5a receptor; complement C5a receptor 1

Product Pictures

ELISA

Figure 1 shows humanized anti-C5aR monoclonal antibodies hAb-J and Q or anti-C5aR monoclonal antibody S5/1 (5 μg/g) coated with peptide PEP1 on ELISA plates at different dilutions. Figure 2 is a combination of diagrams | m1) representing the coupling.

Publications