NeuroMab™ Anti-CASK scaffolding protein BBB Shuttle Antibody, Clone K56A/50

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CASK BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 318-415 (first L27 domain, NSFYGDPPEELPDFSEDPTSSGLLAAERAV SQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSP QIRNPPSDAVQRAKEVLEE) of human Peripheral plasma membrane protein CASK (also known asCalcium/calmodulin-dependent serine protein kinase, Protein lin-2 homologand LIN2, accession number O14936)
Rat: 100% identity (98/98 amino acids identical)
Mouse: 100% identity (98/98 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K56A/50

Applications

WB; IHC; IP; ICC

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CASK

Official Name

CASK

Full Name

CASK

Alternative Names

Calcium/Calmodulin Dependent Serine Protein Kinase; Calcium/Calmodulin-Dependent Serine Protein Kinase (MAGUK Family); Trinucleotide Repeat Containing 8; Protein Lin-2 Homolog; EC 2.7.11.1; HCASK; LIN2; Calcium/Calmodulin-Dependent Serine Protein Kinase Membrane-Associated Guanylate Kinase; Calcium/Calmodulin-Dependent Serine Protein Kinase; Calcium/Calmodulin-Dependent Serin Protein Kinase;

Uniprot ID

O14936

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K56A/50 (left) or N52A/42 (right) TC supe.