NeuroMab™ Anti-CXCR4 BBB Shuttle Antibody(NRZP-1022-ZP3803)
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; Inhib
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
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Research Use Only
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Figure 1 is a series of FACS analyzes demonstrating that anti-CXCR4 scFvs 33 and 48 specifically bind CXCR4. However, these scFvs do not bind the closely related chemokine receptor CCR5.
Figure 2 is a series of FACS analysis graphs showing that scFvs 33 binds to Cf2ThCD4+CXCR4+ cells but not to parental Cf2Th or Cf2ThCD4+CCR5+ cells.
Figure 3 is a series of FACS scans showing that scFvs 33 and 48 do not cross-react with other chemokine receptors such as CXCR6, CXCR1, GPR15 and CXCR2.
Figure 4 is a FACS scan analysis showing that scFv clones 33 and 48 compete with neutralizing anti-CXCR4 monoclonal antibody 12G5 for binding to CXCR4.
Figure 5 shows the results of FACS analysis of the binding of 33 scFv-Fc and 48 scFv-Fc to 293T cells expressing human, mouse and rhesus monkey CXCR4.
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