NeuroMab™ Anti-GABA-A-R-Alpha4 BBB Shuttle Antibody, Clone N398A/34

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABRA4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 410-450 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha4 (also known as Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4 and Gabra4, accession number P28471)
Mouse: 90% identity (37/41 amino acids identical)
Human: 76% identity (30/39 amino acids identical)
<50% identity with other GABA-A receptor Alpha subunits

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N398A/34

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other GABA-A receptor Alpha subunits

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABRA4

Official Name

GABRA4

Full Name

GABA(A)R, Alpha4

Alternative Names

Gamma-Aminobutyric Acid Type A Receptor Alpha4 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor; Alpha 4; GABA(A) Receptor Subunit Alpha-4; GABA(A) Receptor; Alpha 4;