NeuroMab™ Anti-HMGB1 BBB Shuttle Antibody(NRZP-1022-ZP4019)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Inhib; In Vitro; Neut

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

HMGB1

Official Name

HMGB1

Full Name

High-mobility group box 1

Alternative Names

HMGB1; High-mobility group box 1

Product Pictures

ELISA

Figure 1 detects the dissociation curve (zou is the absorbance value after ELISA develops color) of hybridoma cell line 3B1 CGMCC No.2907 excretion monoclonal antibody and people's HMGB1 for ELISA

Figure 2 is the identification of the binding site of the hybridoma cell line 3B1 CGMCC No.2907 secreted monoclonal antibody on HMGB1.

Figure 3 is the specific identification of the secreted monoclonal antibody of the hybridoma cell line 3B1 CGMCC No.2907.

FuncS

Figure 4 shows that the hybridoma cell line 3B1 CGMCC No.2907 secreted monoclonal antibody inhibits the increase of IL-6 mRNA produced by Raw264.7 cells stimulated by human HMGB1.