NeuroMab™ Anti-IL-6 Antibody(NRP-0422-P1512)

Product Overview

Description

The IL-6 antagonist is specific for binding to site II of IL-6, useful for treating IL-6 related diseases, e.g., disease of the eye such as diabetic macular edema.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

In Vitro; In Vivo; Inhib; Antagonist

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

Product Pictures

FuncS

Figure 1 is a graph illustrating experimental results of IVT administration of an anti-IL-6 antibody in a rat CNV model.

Anti-VEGF antibody was administered as a positive control and the negative control was vehicle alone, p = 0.0054 on Day 15 and p = 0.0005 on Day 22 for anti-IL-6 vs. vehicle control.

Inhib

Figure 2 is a graph illustrating the results of a binding experiment testing the ability of the murine 64 antibody to inhibit the binding of IL-6/IL-6R to gp130.

Inhib

Figure 3 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.

Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.

Inhib

Figure 4 is a graph illustrating an experiment in which the ability of 020 to block IL-6 signaling was tested in the absence of excess soluble IL-6Ra.

Experiments were performed in HEK-Blue-IL-6 cells with 0.2 ng/mL IL-6 and 2pg/mL IL6Ra.

Publications