NeuroMab™ Anti-Laforin BBB Shuttle Antibody, Clone N84/37

[CAT#: NRZP-0423-ZP240]

Species Reactivity:: Human

Applications:: WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Laforin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-331 (full-length) of human Laforin (also known as Lafora PTPase, LAFPTPase and EPM2A, accession number O095278)
Rat: 90% identity (296/327 amino acids identical)
Mouse: 89% identity (295/327 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N84/37

Applications

WB; IHC; ICC

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Laforin

Official Name

EPM2A

Full Name

Laforin

Alternative Names

EPM2A; Laforin

Uniprot ID

O95278

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole rat (RBM) or mouse (MBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N84/37 (left) or N52A/42 (right) TC supe.

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