NeuroMab™ Anti-MECP2 BBB Shuttle Antibody, Clone N227/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MECP2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2 (also known as Methyl-CpG-binding protein 2, accession number P51608)
Mouse: 100% identity (13/13 amino acids identical)
Rat: 100% identity (13/13 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N227/21

Applications

DB; IHC

Application Notes

Reacts preferentially with dimethylated peptide than with unmethylated peptide

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

MECP2

Official Name

MECP2

Full Name

MECP2

Alternative Names

Methyl-CpG Binding Protein 2; MeCp-2 Protein; Methyl CpG Binding Protein 2 (Rett Syndrome); Testis Tissue Sperm-Binding Protein Li 41a; Mental Retardation; X-Linked 16; Mental Retardation; X-Linked 79; Methyl CpG Binding Protein 2; Methyl-CpG-Binding Protein 2; Rett Syndrome; AUTSX3;

Uniprot ID

P51608

Product Pictures

IHC

Fig. 1 Adult rat hippocampus immunohistochemistry.

Fig. 2 Bottom right: serial dilutions of BSA-conjugated modified and unmodified peptides dotted onto membrane and probed with N227/21 (left) and loading control (right) TC supe.

Publications