NeuroMab™ Mouse Anti-MeCP2 Monoclonal Antibody (CBP2357)

Product Overview

Description

Methyl CpG binding protein (MECP2), also known as autism susceptibility to X-linked 2 (AUTSX3), is a nuclear protein crucial for normal neuronal function that binds to methylated DNA, forming complexes with histone deacteylases and turning off gene expression. MECP2 expression is an X-linked trait. Loss of MECP2 expression causes Rett Syndrome (also known as RTS, RTT, or RS) a neurological disorder which causes decelerated growth of hands, feet, and the head.

Immunogen

This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2357

Applications

IHC-P

Application Notes

IHC (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1741

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MECP2

Official Name

MECP2

Full Name

Methyl-CpG Binding Protein 2

Alternative Names

Methyl-CpG Binding Protein 2; MeCp-2 Protein; Methyl CpG Binding Protein 2 (Rett Syndrome); Testis Tissue Sperm-Binding Protein Li 41a; Mental Retardation; X-Linked 16; Mental Retardation; X-Linked 79; Methyl CpG Binding Protein 2; Methyl-CpG-Binding Protein 2; Rett Syndrome; AUTSX3;