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Creative Biolabs

iNeu™ Microglia Rett Syndrome MECP2, Disease Model

[CAT#: NCL-7P020]

Microglia Rett Syndrome differentiated from Human iPS cells, frozen

Species:
Human
Cell Types:
Microglia

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Product Overview

Description

Microglia are immune cells that reside in the central nervous system (CNS) and are responsible for basic physiological and pathological processes. Microglia support neuronal homeostasis and promote the formation of neuronal networks through synaptic pruning. Surveillance Microglia can activate, adapt and respond to specific stimuli accordingly.

Microglial dysfunction is considered a key factor in neurodegenerative diseases, including Alzheimer's disease (AD). The limited availability and inconsistency of primary Human microglia limit research and treatment progress.

Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by mutations in the MECP2 gene. MECP2 encodes a 486 amino acid protein that binds to methylated DNA and usually down-regulates transcription.

Features

Human relevance: iNeu Microglia exhibit functional characteristics similar to Human microglia, including phagocytosis and cytokine-mediated inflammatory responses.
Reproducible research: Rigorous quality control and large-scale manufacturing capabilities ensure consistent performance from every lot of iNeu Microglia (>80% TREM2+, IBA1+, CX3CR1+).
Rapid results: iNeu Microglia are fully differentiated cells (not precursors) allowing for more experiments in less time.
Disease lines available: TREM2, SNCA and MeCP2 engineered mutants and isogenic control.

Cell Types

Microglia

Relevant Diseases

Rett Syndrome

Species

Human
Properties

Size

1 Vial: ≥ 1 x 10^6 cells/vial

Tissue Source

Blood

Age

50-59

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Target Details

Target

MECP2
Donor Information

Gender

Male

Donor Age

50-59

Donor Health

Disease

Ethnicity

Caucasian

Additional Donor Information

Genotype: MECP2 (KO)
Publications

Publications (0)

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