iNeu Microglia Rett Syndrome MECP2, Disease Model
Microglia Rett Syndrome differentiated from Human iPS cells, frozen
Microglial dysfunction is considered a key factor in neurodegenerative diseases, including Alzheimer's disease (AD). The limited availability and inconsistency of primary Human microglia limit research and treatment progress.
Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by mutations in the MECP2 gene. MECP2 encodes a 486 amino acid protein that binds to methylated DNA and usually down-regulates transcription.
Reproducible research: Rigorous quality control and large-scale manufacturing capabilities ensure consistent performance from every lot of iNeu Microglia (>80% TREM2+, IBA1+, CX3CR1+).
Rapid results: iNeu Microglia are fully differentiated cells (not precursors) allowing for more experiments in less time.
Disease lines available: TREM2, SNCA and MeCP2 engineered mutants and isogenic control.