Creative Biolabs

iNeu Microglia Rett Syndrome MECP2, Disease Model

[CAT#: NCL-7P020]

Microglia Rett Syndrome differentiated from Human iPS cells, frozen

Species:
Human
Cell Types:
Microglia

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Description
Microglia are immune cells that reside in the central nervous system (CNS) and are responsible for basic physiological and pathological processes. Microglia support neuronal homeostasis and promote the formation of neuronal networks through synaptic pruning. Surveillance Microglia can activate, adapt and respond to specific stimuli accordingly.

Microglial dysfunction is considered a key factor in neurodegenerative diseases, including Alzheimer's disease (AD). The limited availability and inconsistency of primary Human microglia limit research and treatment progress.

Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by mutations in the MECP2 gene. MECP2 encodes a 486 amino acid protein that binds to methylated DNA and usually down-regulates transcription.
Features
Human relevance: iNeu Microglia exhibit functional characteristics similar to Human microglia, including phagocytosis and cytokine-mediated inflammatory responses.
Reproducible research: Rigorous quality control and large-scale manufacturing capabilities ensure consistent performance from every lot of iNeu Microglia (>80% TREM2+, IBA1+, CX3CR1+).
Rapid results: iNeu Microglia are fully differentiated cells (not precursors) allowing for more experiments in less time.
Disease lines available: TREM2, SNCA and MeCP2 engineered mutants and isogenic control.
Cell Types
Microglia
Species
Human
Size
1 Vial: ≥ 1 x 10^6 cells/vial
Tissue Source
Blood
Age
50-59
Mycoplasma Testing
The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.
Shipping
Dry ice.
Storage
Liquid Nitrogen
Research Use Only
For research use only
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Gender
Male
Donor Age
50-59
Donor Health
Rett Syndrome
Ethnicity
Caucasian
Additional Donor Information
Genotype: MECP2 (KO)
For Research Use Only. Not For Clinical Use.
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