NeuroMab™ Anti-Neuropeptide Y BBB Shuttle Antibody, Clone L115/13

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Neuropeptide Y BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 28-97 (all but signal peptide) of human NPY (also known as Neuropeptide Y, Neuropeptide tyrosine, C-flanking peptide of NPY and CPON, accession number P01303)
Rat: 96% identity (67/70 amino acids identical)
Mouse: 94% identity (66/70 amino acids identical)
~50% identity with Peptide YY

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

L115/13

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Neuropeptide Y

Official Name

NPY

Full Name

NPY/Neuropeptide Y

Alternative Names

Prepro-Neuropeptide Y

Uniprot ID

P01303

Product Pictures

IHC

Fig. 1 Adult rat cortex immunohistochemistry.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Array tomography immunofluorescence of Lowicrylembedded sections from adult mouse cortex layer 2/3 with L115/13 (green), GABA (red) and DAPI (blue). Volume reconstruction of 35 serial 70 nm sections show two NPY-positive neurons with varying levels of GABA reactivity, as well as some NPYreactive axonal varicosities.

Publications