NeuroMab™ Anti-Notch1 BBB Shuttle Antibody(NRZP-1022-ZP3206)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; WB; IHC; Inhib; In Vitro

Relevant Diseases

Alzheimer's Disease; Epilepsy; Pain

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Notch1

Official Name

notch 1

Full Name

notch 1

Alternative Names

AOVD1; Translocation-associated notch protein TAN-1; NEXT; hN1; AOS5; NICD; Notch 1; Neurogenic locus notch homolog protein 1; TAN1

Product Pictures

Neut

Figure 1 shows the neutralizing activity of humanized 438 VH1.1/VL1.8 and rat 438 antibodies against Notch1-dependent signaling in human Notch1 reporter cells.

Neut

Figure 2 shows the neutralizing activity of humanized 438 VH1.1/VL1.8 and rat 438 antibodies on Notch1-dependent signaling in mouse Notch1 reporter cells.

Neut

Figure 3 shows the neutralizing activity of humanized 351 mutant and rat 351-mIgG1 in a human Notch1-dependent signaling reporter assay.

Neut

Figure 4 shows the neutralizing activity of humanized 351 mutants and rat 351-mIgG1 in a mouse Notch1-dependent signaling reporter assay.

Figure 5 Treatment of HBP-ALL cells with increasing concentrations of rat 438-mIgG1 and humanized 438VH1.1/VL1.8 significantly inhibited constitutive Notch1 activation.

IHC

Figure 6 shows the histochemical identification of secretory goblet cells using Alcian blue staining on ileal sections of mouse intestine obtained from a Calu-6 efficacy study.

IHC

Figure 7 shows representative Figures of intestinal crypts stained with Ki67, where Ki67 staining was reduced in animals treated with rat 351-mIgG1 at the bottom of the crypts

Publications