NeuroMab™ Anti-S100A5 BBB Shuttle Antibody, Clone N176A/35

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-S100A5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-93 (full-length) of rat S100A5 (also known as S100 calcium-binding protein A5 and S-100D, accession number P63083)
Mouse: 100% identity (93/93 amino acids identical)
Human: 93% identity (87/93 amino acids identical)
~50% identity with S100A4 and S100A6

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N176A/35

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with S100A4 or S100A6 (based on KO validation results)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

S100A5

Official Name

S100A5

Full Name

S100A5

Alternative Names

S100 Calcium Binding Protein A5; S100 Calcium-Binding Protein A5; S100D; Protein S100-A5; Protein S-100D;

Uniprot ID

P63083

Product Pictures

Fig. 1 Immunoblot versus adult rat brain membranes (RBM) and whole brain homogenates from S100A5-tauGFP (targeted deletion of S100A5 and replaced with coding region of tau fused to GFP) heterozygote (Het) and KO mice and probed with N176A/35 TC supe (left) and rabbit anti-S100A5 antibody (right).

Publications