NeuroMab™ Anti-SPP1 Antibody(NRP-0422-P696)

Figure 1 The protective effect of chimeric antibody H1A18 on joint bone in CIA mice.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 2 The effect of chimeric antibody H1A18 on the level of D-pyr in the urine of CIA mice.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 3 The effect of chimeric antibody H1A18 on the level of TRAP5b in serum of CIA mice.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 4 The effect of chimeric antibody H1A18 on the number of osteoclasts in CIA mice.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 5 Changes in the number of tibial osteoclasts in OVX model mice treated with chimeric antibody H1A18.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 6 Effect of chimeric antibody H1A18 on mouse osteoclast differentiation.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 7 Effect of chimeric antibody H1A18 on bone resorption function of mouse osteoclasts.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.