NeuroMab™ Anti-OPN BBB Shuttle Antibody(NRZP-1022-ZP2616)

Fig.1 The protective effect of chimeric antibody H1A18 absorbing CIA mice joint bone.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.2 chimeric antibody H1A18 is to the influence of D-pyr level in the CIA mouse urine.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.3 chimeric antibody H1A18 is to the influence of TRAP5b level in the CIA mice serum.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.4 chimeric antibody H1A18 is to the influence of CIA mouse amount of osteoclast.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.5 OVX model mice is through the variation of chimeric antibody H1A18 treatment ossa tibiale posterius amount of osteoclast.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.6 chimeric antibody H1A18 is to the influence of mouse osteoclast differentiation.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.

Fig.7 chimeric antibody H1A18 is to the influence of mouse osteoclastic bone absorptive function.

EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.