NeuroMab™ Anti-OPN BBB Shuttle Antibody(NRZP-1022-ZP2618)
[CAT#: NRZP-1022-ZP2618]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; IHC; Inhib; In Vitro; In Vivo
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
C-terminal amino acid sequence YGLR
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
WB; ELISA; IHC; Inhib; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
SPP1
Official Name
SPP1
Full Name
Secreted phosphoprotein 1
Alternative Names
BNSP;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Product Pictures
WB
Fig.1 shows the results of the western blotting conducted on mOPN and rOPN.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
Inhib
Fig.2 shows that the 39E1 antibody and 34E3 antibody inhibit adhesion of a murine melanoma cell strain to mOPN-5.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
Inhib
Fig.3 shows that the 39E1 antibody and 34E3 antibody inhibit adhesion of a murine melanoma cell strain to mOPN-7.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
WB
Fig.4 shows the results that the 39E1 antibody and 34E3 antibody recognize the polypeptides (I), (II) and hOPN N-half .
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
WB
Fig.5 shows the results that the 39E1 antibody and 34E3 antibody do not react with hOPN but only with hOPN N-half.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
Publications
Publications (0)
Cell Assay Reagents
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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