NeuroMab™ Anti-UNC5B Antibody(NRP-0422-P1929)

Product Overview

Description

The anti-Unc5B antibody can be used to modulate angiogenesis and treat or prevent disorders associated with abnormal angiogenesis.

Immunogen

Unc5B ECD

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

WB; ELISA; FC; In Vitro; Block; In Vivo

Relevant Diseases

Parkinson's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

UNC5B

Official Name

UNC5B

Full Name

Unc-5 Netrin Receptor B

Alternative Names

Unc-5 Netrin Receptor B; P53-Regulated Receptor For Death And Life Protein 1; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; P53RDL1; UNC5H2; Transmembrane Receptor Unc5H2;

Gene ID

60630(Rat)

Uniprot ID

O08722(Rat)

Product Pictures

FCM

Figure 1 illustrates binding curve data demonstrating that anti-Unc5B antibodies interfere with Netrin-1 binding to Unc5B.

FuncS

Figure 2 illustrates corneal micropocket assay data from postnatal day 5 mice treated with anti-Unc5B demonstrating that antibody treatment results in increased corneal neovascularization.

Representative images of FITC-dextran-stained corneas with and without antibody treatment are shown.

Publications