NeuroMab™ Anti-UNC5B BBB Shuttle Antibody(NRZP-1022-ZP3302)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

Unc5B ECD

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

WB; ELISA; FC; In Vitro; Block; In Vivo

Relevant Diseases

Parkinson's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

UNC5B

Official Name

UNC5B

Full Name

Unc-5 Netrin Receptor B

Alternative Names

Unc-5 Netrin Receptor B; P53-Regulated Receptor For Death And Life Protein 1; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; P53RDL1; UNC5H2; Transmembrane Receptor Unc5H2;

Product Pictures

FCM

Figure 1 illustrates binding curve data demonstrating that anti-Unc5B antibodies interfere with Netrin-1 binding to Unc5B.

FuncS

Figure 2 illustrates corneal micropocket assay data from postnatal day 5 mice treated with anti-Unc5B demonstrating that antibody treatment results in increased corneal neovascularization.

Representative images of FITC-dextran-stained corneas with and without antibody treatment are shown.

Publications