NeuroMab™ Anti-WAVE1/SCAR BBB Shuttle Antibody, Clone K91/36

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Wave 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 477-498 (CQVIPASEPKRHPSTLPVISDAR) of human WAVE1 (also known as Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Verprolin homology domain-containing protein 1, KIAA0269, WASF1 and SCAR1, accession number Q92558)
Rat: 95% identity (21/22 amino acids identical)
Mouse: 95% identity (21/22 amino acid identical)
<50% identity with WASF3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K91/36

Applications

WB; IHC; IP; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Wave 1

Official Name

WASF1

Full Name

WAVE1/SCAR

Alternative Names

WASF1; SCAR1; WAVE; WAVE1; WAS protein family member 1; WASP family member 1; NEDALVS

Uniprot ID

Q92558

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K91/36 (left) or N52A/42 (right) TC supe.