NeuroMab™ Mouse Anti-CRMP2 Monoclonal Antibody (CBP2250)

Product Overview

Description

CRMP2 is a ubiquitously expressed, microtubule-associated protein. In the central nervous system, CRMP2 forms homotetramers or heterotetramers with other CRMP proteins during development and regulates axonal growth and guidance, neuronal growth cone collapse, and migration. The C-terminal sequence of CRMP2 is highly homologous to that of Tau protein. Phosphorylation of CRMP2 alters its interaction with microtubules and affects its protein scaffolding function. Similar to Tau, CRMP2 is a biochemically prominent component of Neurofibrillary tangles. These finding suggest that CRMP2 may be an etiologically significant protein and a potential therapeutic target for Alzheimer's disease.

Species Reactivity

Human; Mpuse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2250

Applications

WB; IHC-P

Application Notes

WB (0.5-1.0 µg/mL); IHC-P (0.5-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1668

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CRMP2

Official Name

CRMP2

Full Name

Collapsin response mediator protein 2

Alternative Names

DPYSL2; Collapsin Response Mediator Protein 2; Dihydropyrimidinase-Related Protein 2

References

1. Hensley K, et al. 2016. J Alzheimers dis. 53(1):1
2. Quach TT, et al. 2015. Mol Psychiatry. 20(9):1037
3. Ip JP, et la. 2014. Neuroscientist. 20(6):589

Publications