NeuroMab™ Mouse Anti-HNRNPA1 Monoclonal Antibody (CBP2507)
[CAT#: NAB2010641LS]
Anti HNRNPA1 Monoclonal Antibody [Alexa Fluor 488]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- IHC-P
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multi-purpose RNA binding protein involved in RNA metabolism and DNA genomic stability in normal and pathological conditions. hnRNP A1 is ubiquitously expressed and usually associates with nascent RNA polymerase II transcripts. hnRNP A1 is abundantly expressed in neuronal cells and reproductive tissue. Loss of hnRNP A1 has been observed in several neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, amytrophic lateral sclerosis. Structurally, hnRNPA1 has two RNA recognition motifs, which are post-translationally modified to alter its nuclear pore shuttling properties and RNA interaction.
Immunogen
Partially purified HeLa HNRNPA1 protein
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a, κ
Clone Number
CBP2507
Applications
IHC-P
Application Notes
IHC-P (1.0-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1834
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide
Concentration
0.5 mg/ml
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Bekenstein U, et al. 2013. Mol Cell Neurosci. 56:436-46.
2. Jean-Philippe J, et al. 2014. Biochim Biophys Acta. 1839(4): 251-258.
2. Jean-Philippe J, et al. 2014. Biochim Biophys Acta. 1839(4): 251-258.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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