NeuroMab™ Mouse Anti-CD206 Monoclonal Antibody (CBP2559)

Product Overview

Description

Mouse anti-human CD206 monoclonal antibody, recognizes human macrophage mannose receptor 1, also known as CD206 or C-type lectin domain family 13 member D-like. CD206 is a type I single-pass transmembrane glycoprotein of ~175 kDa, which belongs to the pattern recognition receptor (Paveley et al., 2011). CD206 has a variety of carbohydrate recognition motifs and acts as a receptor for bacteria, fungi and other pathogens (Ezekowitz et al., 1990). CD206 is mainly expressed in tissue macrophages and dendritic cells (Engering et al., 1997), and can also be found in subpopulations of endothelial cells (Pack et al., 2007) and sperm cells (Cardona-Maya et al., 2006). CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.

Immunogen

Purified human mannose receptor.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2559

Applications

FC; IF; IHC-Fr; WB

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1863

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

0.5 mg/ml

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD206

Official Name

MRC1

Full Name

Mannose Receptor C-Type 1

Alternative Names

Mannose Receptor C-Type 1; Macrophage Mannose Receptor 1-Like Protein 1; C-Type Lectin Domain Family 13 Member D; Mannose Receptor, C Type 1-Like 1; Human Mannose Receptor; CLEC13DL; CLEC13D; MRC1L1; MMR;

Gene ID

4360(Human); 17533(Mouse); 291327(Rat)

Uniprot ID

P22897(Human); Q61830(Mouse)

References

1. Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.
2. Emara, M. et al. (2011) Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity.
3. Chang, S.K. et al. (2008) B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturation.
4. MacKinnon, A.C. et al. (2008) Regulation of alternative macrophage activation by galectin-3.

Publications