Mouse Anti-CD206 Monoclonal Antibody (CBP2620)

Product Overview

Description

CD206 is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

Expression Host

Mammalian cells

Immunogen

Peptide

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2620

Applications

FC; IHC; IP; WB; ELISA

Application Notes

IHC : 1:20-1:200; IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD206

Official Name

CD206

Full Name

Mannose receptor, C type 1

Alternative Names

CD206; CLEC13D; Macrophage mannose receptor 1; Mannose receptor; mannose receptor; C type 1; MMR; MRC1

Gene ID

4360(Human); 17533(Mouse); 291327(Rat)

Uniprot ID

P22897(Human); Q61830(Mouse)

References

1. Tseng, W. C., Tsai, M. T., Chen, N. J., & Tarng, D. C. (2020). Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation. International journal of molecular sciences, 21(17), 5966. 2. Feng, H., Yin, Y., Ren, Y., Li, M., Zhang, D., Xu, M.,... & Kang, J. (2020). Effect of CSE on M1/M2 polarization in alveolar and peritoneal macrophages at different concentrations and exposure in vitro. In Vitro Cellular & Developmental Biology-Animal, 56(2), 154-164. 3. Shi, X. D., Chen, L. W., Li, S. W., Sun, X. D., Cui, F. Z., & Ma, H. M. (2018). The observed difference of RAW264. 7 macrophage phenotype on mineralized collagen and hydroxyapatite. Biomedical Materials, 13(4), 041001.

Publications