NeuroMab™ Mouse Anti-TUBA1B Monoclonal Antibody (CBP2681)

Product Overview

Description

Alpha-tubulin belongs to a large superfamily of tubulin proteins. There are a number of different subtypes that have a molecular weight of ~50kDa and are able to bind to beta-tubulin, forming a heterodimer that polymerises to microtubules as part of the cytoskeleton. These maintain cell structure, provide platforms for intracellular transport and are also involved in cell division.

Expression Host

Mammalian cells

Immunogen

Alpha Tubulin fusion protein Ag18034

Species Reactivity

Human; Mouse; Rat; Dog

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2681

Applications

FC; IF; IHC; IP; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1890

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1733 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TUBA1B

Official Name

TUBA1B

Full Name

Alpha Tubulin

Alternative Names

alpha Tubulin; Alpha tubulin ubiquitous; TUBA1B; tubulin; Tubulin alpha; tubulin; alpha 1b; α-tubulin

Gene ID

10376(Human); 22143(Mouse); 500929(Rat)

Uniprot ID

P68363(Human); P05213(Mouse); Q6P9V9(Rat)

References

1. Liu, J., Yuan, Y., Xu, J., Xiao, K., Xu, Y., Guo, T.,... & Zheng, H. (2018). β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling. Frontiers in Immunology, 9, 2930. 2. Simmons, A. J., Park, R., Sterling, N. A., Jang, M. H., van Deursen, J. M., Yen, T. J.,... & Kim, S. (2019). Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Human molecular genetics, 28(11), 1822-1836. 3. Chang, C. H., Zanini, M., Shirvani, H., Cheng, J. S., Yu, H., Feng, C. H.,... & Cigna, S. M. (2019). Atoh1 controls primary cilia formation to allow for SHH-triggered granule neuron progenitor proliferation. Developmental Cell, 48(2), 184-199.

Publications