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Creative Biolabs
Product

Mouse Anti-Human CD133 Monoclonal Antibody (CBP4242)

[CAT#: NAB210109LS]

Anti-CD133 Monoclonal Antibody [Alexa Fluor 594 ]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC-P

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Product Overview

Description

CD133, also known as Prominin-1 and AC133 antigen, is a 120 kD pentaspan glycoprotein with 5 transmembrane domains. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marker for murine neuroepithelial cells and some embryonic epithelia. Later on, CD133 was found on other stem cells, including endothelial progenitor cells, glioblastomas, neuronal, and glial stem cells. In addition to stem cells for normal tissue, CD133 was found on cancer cells, such as some leukemia cells and brain tumor cells. Although the biological function of CD133 is not completely understood, CD133 has been extensively used as a stem cell marker for normal and cancerous tissues.

Immunogen

Recombinant partial human CD133 protein.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4242

Applications

IHC-P

Application Notes

IHC-P (2.5-10 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

CD133

Official Name

PROM1

Full Name

CD133 antigen

Alternative Names

PROM1; AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4; prominin 1

Gene ID

8842 (Human); 19126 (Mouse)

Uniprot ID

O43490 (Human); O54990 (Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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