Human CHO-K1/CMKLR1/Gα15 Stable Cell Line

[CAT#: NCL20120039CR]

Chemokine Receptor-like 1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The orphan receptor ChemR23 (also referred to as CMKLR1 or DEZ) is a G-protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. ChemR23 is also a Gαi-linked receptor expressed primarily by monocytes, MΦs, and plasmacytoid dendritic cells. CMKLR1 has been shown to be expressed by DC generated in vitro from monocytes, to mediate their migration to the proteolytically regulated chemoattractant chemerin, and CMKLR1 may be a key mediator of pDC recruitment from the blood into tissue sites enriched in active chemerin.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

CMKLR1

Family

Chemerin receptor

Strain

CMKLR1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

CMKLR1

Official Name

CMKLR1

Alternative Names

chemerin receptor; Gpcr27; chemokine-like receptor 1; ChemR23; DEZ; CMKLR1; cDEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; CHEMERINR; orphan G-protein coupled receptor; Dez; CHEMR23; RvE1; RVER1; resolvin E1 receptor; G-protein coupled chemoattractant-like receptor; chemokine receptor-like 1; TIG2 receptor; tazarotene induced gene 2 receptor

Gene ID

1240(Human); 14747(Mouse); 60669(Rat)

Uniprot ID

Q99788(Human); P97468(Mouse); O35786(Rat)

References

1. Ghosh, E., Dwivedi, H., Baidya, M., Srivastava, A., Kumari, P., Stepniewski, T.,.. & Roy, D. (2019). Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms. Cell reports, 28(13), 3287-3299. 2. Hernandez-Gordillo, V., & Chmielewski, J. (2014). Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds. Biomaterials, 35(26), 7363-7373.

Publications