Human CHO-K1/MC2/Gα15 Stable Cell Line

[CAT#: NCL20120084CR]

MC2 Melanocortin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The melanocortin receptor 2 is Gs-coupled GPCRs expressed in zona fasciculata of the adrenal cortex placental and stimulates production of cortisol. MC2 is a member of the rhodopsin family of 7-transmembrane and it's also known as the ACTH receptor or corticotropin receptor because it is specific for ACTH alone. Activation of the MC2 receptor initiates a cascade of events affecting multiple steps in corticoid steroidogenesis.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

MC2

Family

Melanocortin receptor

Strain

MC2/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

MC2

Official Name

MC2

Alternative Names

MC2 receptor; MC2R; ACTH-R; ACTH; ACTHR; melanocortin 2 receptor; adrenocorticotropic hormone receptor

Gene ID

4161(Human); 17203(Mouse); 25726(Rat)

Uniprot ID

P33032(Human); P41149(Mouse); P35345(Rat)

References

1. Ramírez, M. P., Rivera, M., Quiroga-Roger, D., Bustamante, A., Vega, M., Baez, M.,.. & Wilson, C. A. (2017). Single molecule force spectroscopy reveals the effect of BiP chaperone on protein folding. Protein Science, 26(7), 1404-1412. 2. Wang, I., Chen, S. Y., & Hsu, S. T. D. (2015). Unraveling the folding mechanism of the smallest knotted protein, MJ0366. The Journal of Physical Chemistry B, 119(12), 4359-4370.

Publications