Human CHO-K1/OX2 Stable Cell Line

[CAT#: NCL20120104CR]

OX2 Orexin Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Hypocretin (orexin) receptor 2 is a human protein encoded by the HCRTR2 gene. Orexin A and orexin B are neuropeptides originally identified as endogenous ligands for OX2. Orexin neuropeptides are produced by a small group of neurons in the lateral hypothalamic and perifornical areas, a region that is classically implicated with the control of mammalian feeding behavior. Orexin neurons that project throughout the central nervous system to nuclei are known to be important in the control of feeding, sleep-wakefulness, neuroendocrine homeostasis, and autonomic regulation.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

OX2

Family

Orexin receptor

Strain

OX2 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

OX2

Official Name

OX2

Alternative Names

OX2 receptor; hypocretin receptor type 2; OX2R; hypocretin (orexin) receptor 2; hypocretin receptor 2; orexin receptor type 2; ox-2-R; mOXR2; mOX2aR; mOX2bR

Gene ID

4345(Human)

Uniprot ID

P41217(Human)

References

1. Watanabe, H., Matsushita, N., Shimizu, Y., Iikuni, S., Nakamoto, Y., Togashi, K., & Ono, M. (2019). Synthesis and characterization of a novel 18 F-labeled 2, 5-diarylnicotinamide derivative targeting orexin 2 receptor. MedChemComm, 10(12), 2126-2130.

Publications