Human CHO-K1/PAR2/Gα15 Stable Cell Line

[CAT#: NCL20120122CR]

PAR2 Proteinase-activated Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The activated coagulation factors VIIa and Xa, have been identified as serine proteinases able to activate mammalian PAR-2. As already indicated, PAR-2 is believed to be involved in inflammation. This role for PAR-2 implies that elastase and cathepsin G would paradoxically display an anti-inflammatory property by disarming PAR-2.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

PAR2

Family

Proteinase-activated receptor

Strain

PAR2/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

PAR2

Official Name

PAR2

Alternative Names

PAR2; PAR-2; GPR11; proteinase-activated receptor-2; Proteinase-activated receptor-2 G protein-coupled receptor 11; Proteinase-activated receptor-2; G protein-coupled receptor 11; coagulation factor II receptor-like 1; proteinase-activated receptor 2; thrombin receptor-like 1; Protease-activated receptor-2; Gpcr11

Gene ID

2150(Human); 14063(Mouse); 116677(Rat)

Uniprot ID

P55085(Human); P55086(Mouse); Q63645(Rat)

References

1. McKernan, K. J., Helbert, Y., Kane, L. T., Ebling, H., Zhang, L., Liu, B.,.. & Concepcion, G. (2020). Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes. BioRxiv. 2. Wayengera, M., Mwebaza, I., Welishe, J., Bayiyana, A., Kateete, D. P., Wampande, E.,.. & Kyobe, S. (2017). Immuno-diagnosis of Mycobacterium tuberculosis in sputum, and reduction of timelines for its positive cultures to within 3 h by pathogen-specific thymidylate kinase expression assays. BMC research notes, 10(1), 368.

Publications