Product
Human HEK293/AT1 Stable Cell Line
[CAT#: NCL20120025CR]
Angiotensin Receptor 1 Stable Cell Line
- Species:
- Human
- Applications:
- GPCR Screening
- Cell Types:
- HEK293; GPCR Cell
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
α1-ARs belong to the G protein-coupled receptor family and consist of single polypeptide chains predicted to have seven transmembrane spanning domains. With similar pharmacological and signaling properties, α1-AR subtypes act through Gq/11 proteins to activate phospholipase C, increase both inositol 1,4,5-trisphosphate production and intracellular Ca2+. Once activated by binding, α1-ARs initiate the cellular pathways leading to the regulation of physiological effects, including blood pressure maintenance, glucose metabolism, renal sodium reabsorption, and cardiac inotropy.
Cell Types
HEK293; GPCR Cell
Applications
GPCR Screening
Research Areas
GPCR; Neural Signal Transduction
Species
Human
Properties
Size
>1x10^6 Cells
Form
Frozen cells
Culture Medium
DMEM, 10% FBS, 300 μg/ml G418
Freeze Medium
45% culture medium, 45% FBS, 10% DMSO
Receptor
AT1
Family
Angiotensin receptor
Strain
AT1 Cell Line
Cell Purity
>95%
Shipping
Dry ice
Storage
Liquid nitrogen immediately upon delivery
Handling Advice
Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
repeated exposure.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Warnings
Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.
Target Details
Target
AT1
Official Name
AT1
Alternative Names
AGTR1B; AT2R1; AT2R1B; angiotensin II receptor type 1; AII-I; AII alpha; angiotensin receptor 1B; AT1R; angiotensin II type-1 receptor; angiotensin II type-1B receptor; angiotensin receptor 1; AT1A; AT1R; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor; type 1a; angiotensin II type-1A receptor; vascular type-1 angiotensin II receptor; Agtr-1b; Angtr-1b;
References
1. Montagna, E., Crux, S., Luckner, M., Herber, J., Colombo, A. V., Marinković, P.,.. & Sgobio, C. (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia, 67(5), 985-998. 2. Xu, Y., Wu, X., Wang, S., Yang, C., Li, Y., & Cao, Y. (2019). Hydroxyapatite Nanoparticle-Crosslinked Peptide Hydrogels for Three-Dimensional Culture and Differentiation of MC3T3-E1 Osteoblasts. Journal of biomedical nanotechnology, 15(12), 2351-2362. 3. Lan, J., Rollins, J. A., Zang, X., Wu, D., Zou, L., Wang, Z.,.. & Chen, D. (2019). Translational regulation of non-autonomous mitochondrial stress response promotes longevity. Cell reports, 28(4), 1050-1062.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
