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Creative Biolabs
Product

Human HEK293/H1 Stable Cell Line

[CAT#: NCL20120072CR]

H1 Histamine Receptor Stable Cell Line

Species:
Human
Applications:
GPCR Screening
Cell Types:
HEK293; GPCR Cell

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Product Overview

Description

The H1 histamine receptor is expressed primarily in the lungs, vasculature, and brain. The H1 mediates the contraction of smooth muscles, neurotransmission in the central nervous system, the release of catecholamine from adrenal medulla, and increases in capillary permeability due to contraction of terminal venules. H1's role in inflammatory responses makes its antagonist suitable for treating allergies.

Cell Types

HEK293; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR

Species

Human
Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

H1/HRH1

Family

Histamine receptor

Strain

H1 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.
Target Details

Target

HRH1

Official Name

HRH1

Alternative Names

Histamine receptor H1; H1 receptor; Hisr; H1R; HH1R; histamine H1 receptor; Bphs; Hir

Gene ID

3269(Human); 15465(Mouse); 24448(Rat)

Uniprot ID

P35367(Human); P70174(Mouse); P31390(Rat)
References

1. Montagna, E., Crux, S., Luckner, M., Herber, J., Colombo, A. V., Marinković, P.,.. & Sgobio, C. (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia, 67(5), 985-998. 2. Xu, Y., Wu, X., Wang, S., Yang, C., Li, Y., & Cao, Y. (2019). Hydroxyapatite Nanoparticle-Crosslinked Peptide Hydrogels for Three-Dimensional Culture and Differentiation of MC3T3-E1 Osteoblasts. Journal of biomedical nanotechnology, 15(12), 2351-2362. 3. Lan, J., Rollins, J. A., Zang, X., Wu, D., Zou, L., Wang, Z.,.. & Chen, D. (2019). Translational regulation of non-autonomous mitochondrial stress response promotes longevity. Cell reports, 28(4), 1050-1062.
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For Research Use Only. Not For Clinical Use.
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