NeuroMab™ Anti-Ankyrin-B BBB Shuttle Antibody, Clone N105/17

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Ankyrin-B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 203-496 (ankyrin repeats 6 to 14) of human Ankyrin-B (also known as Ankyrin-2, Brain ankyrin, Non-erythroid Ankyrin and ANK2, accession number Q01484)
Mouse: 99% identity (292/294 amino acids identical)
Rat: 98% identity (291/294 amino acids identical)
~80% identity with Ankyrin-G

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N105/17

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Ankyrin-G

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Ankyrin-B

Official Name

ANK2

Full Name

Ankyrin-B

Alternative Names

ANK2; ANK-2; LQT4; brank-2; ankyrin 2; neuronal; ankyrin 2

Uniprot ID

Q01484

Product Pictures

Fig. 1 Immunoblot against crude C. elegans worm extracts and membranes from adult rat brain (RBM) probed with N105/17 TC supe.

Fig. 2 Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N105/17 (left) or N52A/42 (right) TC supe