NeuroMab™ Anti-FOS BBB Shuttle Antibody, Clone N486/32

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-c-Fos BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-377 (full-length) of human FOS (also known as Proto-oncogene c-Fos, G0/G1 switch regulatory protein 7 and G0S7, accession number P01100)
Rat: 94% identity (355/377 amino acids identical)
Mouse: 94% identity (353/377 amino acids identical)
<50% identity with FOSL2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N486/32

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

c-Fos

Official Name

FOS

Full Name

c-Fos

Alternative Names

FOS; AP-1; C-p55; Fos proto-oncogene; AP-1 transcription factor subunit

Uniprot ID

P01100

Product Pictures

Fig. 1 Immunoblot against crude brain low-speed pellets from untreated adult rats (RBLSP), adult rats treated with kainic acid to induce seizures (RBLSP seiz) and adult rats treated with saline (RBLSP non-seiz) probed with N486/32 (left), N408/62 (middle) and N52A/42 (right) TC supe