NeuroMab™ Anti-GABA-A-R-Alpha2 BBB Shuttle Antibody, Clone N399/19

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (also known as Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2 and Gabra2, accession number P23576)
Mouse: 100% identity (36/36 amino acids identical)
Human: 97% identity (35/36 amino acids identical)
<50% identity with GABA-A-R-Alpha1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N399/19

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABA-A-R-Alpha1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABA A Receptor Alpha 2

Official Name

GABRA2

Full Name

GABA(A)R, Alpha2

Alternative Names

GABRA2; gamma-aminobutyric acid type A receptor alpha2 subunit

Uniprot ID

P23576

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and GABA-A-R-Alpha2 knockout (KO) mouse brains probed with N399/19 (left) and N52A/42 (right) TC supe.