NeuroMab™ Anti-GABA-A-R-Alpha2 BBB Shuttle Antibody, Clone N399/19
[CAT#: NRZP-0423-ZP110]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (also known as Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2 and Gabra2, accession number P23576)
Mouse: 100% identity (36/36 amino acids identical)
Human: 97% identity (35/36 amino acids identical)
<50% identity with GABA-A-R-Alpha1
Mouse: 100% identity (36/36 amino acids identical)
Human: 97% identity (35/36 amino acids identical)
<50% identity with GABA-A-R-Alpha1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N399/19
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with GABA-A-R-Alpha1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABA A Receptor Alpha 2
Official Name
GABRA2
Full Name
GABA(A)R, Alpha2
Alternative Names
GABRA2; gamma-aminobutyric acid type A receptor alpha2 subunit
Uniprot ID
P23576
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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