NeuroMab™ Anti-Notch1 BBB Shuttle Antibody, Clone N253/32

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Notch 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (also known as Neurogenic locus notch homolog protein 1, hN1, Translocationassociated notch protein, TAN-1, Motch A, mT14, p300 and Motch, accession number Q01705) Rat: 93% identity (185/197 amino acids identical)
Human: 84% identity (166/197 amino acids identical)
~40% identity with Notch2, Notch3 and Notch4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N253/32

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Notch2 or Notch3

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Notch 1

Official Name

NOTCH1

Full Name

Notch1

Alternative Names

Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); Notch Homolog 1; Translocation-Associated (Drosophila); Notch Homolog 1; Translocation-Associated;

Uniprot ID

Q01705

Product Pictures

Fig. 1 Immunoblot against adult rat brain membrane (RBM) or lowspeed pellet (RBLSP) fractions denatured at 95℃ for 5 min or 37℃ for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.

Publications