NeuroMab™ Anti-OPN BBB Shuttle Antibody(NRZP-1022-ZP2613)
[CAT#: NRZP-1022-ZP2613]
- Host Species:
- Chimeric; Humanized
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; Inhihb; ELISA; In Vitro; In Vivo
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Lot Number
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Chimeric; Humanized
Applications
WB; Inhihb; ELISA; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
SPP1
Official Name
SPP1
Full Name
Secreted phosphoprotein 1
Alternative Names
BNSP;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Product Pictures
ELISA
Fig.1 shows the result of measuring the affinity of the OPN small peptide and the anti-OPN chimeric antibody.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
ELISA
Fig.2 shows the results of measuring the affinity of the anti-OPN chimeric antibody.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
Inhib
Fig.3 shows the results of inhibiting the proliferation of non-small cell lung cancer cell A549 by the anti-OPN chimeric antibody (antibody 72B) in example 6 for 48 hours.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
FuncS
Fig.4 is a tumor growth curve.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
ELISA
Fig.5 shows the result of measuring the affinity of the OPN small peptide and the anti-OPN chimeric antibody.
EC50 values were calculated from the 4-parameter fit equation using Prism Graphpad using the data from FIG.10. A2=2.6 ng/mL, A6=3.2 ng/mL; E5=4.0 ng/mL and G7=93.2 ng/mL.
Publications
Publications (0)
Neural Antibodies
Cell Assay Reagents
For Research Use Only. Not For Clinical Use.
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