NeuroMab™ Anti-OPN BBB Shuttle Antibody,Clone NR1374P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Chimeric; Humanized

Clone Number

NR1374P

Applications

ELISA; Block; Inhib; In Vitro; In vivo

Relevant Diseases

Alzheimer's Disease; Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SPP1

Official Name

SPP1

Full Name

Secreted phosphoprotein 1

Alternative Names

BNSP;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;

Product Pictures

Inhib

Fig.1 shows graphs depicting the inhibition of RGD-dependent and RGD-independent cell adhesion between nOPN and a9-transformed SW480 cell by the murine antibody 2K1.

Experimental result shows that the cell of S-113-6 antibody treatment significantly reduces than the ability of Mork group (PBS) and the cell migration of irrelevant antibody control group in the 48hrs.