NeuroMab™ Anti-PARIS/ZNF746 BBB Shuttle Antibody, Clone N196/16

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PARIS BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-322 (N-terminus) of human ZNF746 (also known as Zinc finger protein 746, Parkin-interacting substrate, Zfp746 and PARIS, accession number Q6NUN9)
Mouse: 96% identity (312/323 amino acids identical)
Rat: 96% identity (312/323 amino acids identical)>50% identity with ZNF783, ZNF282 and ZNF398

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N196/16

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with ZNF783 or ZNF398

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PARIS

Official Name

ZNF746

Full Name

PARIS/ZNF746

Alternative Names

PARIS

Uniprot ID

Q6NUN9

Product Pictures

Fig. 1 Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N196/16 (left) or N52A/42 (right) TC supe.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged ZNF746, V5-tagged ZNF398, V5-tagged ZNF783 or untagged Kv2.1 plasmid and probed with N196/16 TC supe (left), N86/8 TC supe (middle) or Rabbit anti-V5.