NeuroMab™ Anti-SPP1 Antibody(NRP-0422-P693)

Figure 1 shows the results of measuring the affinity of the OPN small peptide and the anti-OPN chimeric antibody.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 2 shows the results of measuring the affinity of the anti-OPN chimeric antibody.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 3 is the result of the anti-OPN chimeric antibody (antibody 72B) of Example 6 inhibiting the proliferation of non-small cell lung cancer cell A549 for 48 hours.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 4 is the tumor growth curve.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.

Figure 5 shows the results of measuring the affinity of the OPN small peptide and the anti-OPN chimeric antibody.

EC50 values were calculated from a 4 parameter fit equation using Prism Graphpad using the data from Figure 10. A2=2.6 ng/ml, A6=3.2 ng/ml; E5=4.0 ng/ml, G7=93.2 ng/ml.