NeuroMab™ Anti-Tau40 BBB Shuttle Antibody(NRZP-1022-ZP3065)
[CAT#: NRZP-1022-ZP3065]
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Human
Applications
WB; ELISA; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
Tau40
Official Name
MAPT
Alternative Names
MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins
Product Pictures
IHC
Figure 1 NI-105.4E4 binds neurofibrillary tangles and expresses human TauP301L (NFT), dystrophic neural processes, and neurofibrillary cords in AD mouse brains.
ELISA
Figure 2 Human IgG levels in plasma after intraperitoneal administration of 30 mg/kg NI-105.4E4 or NI-105.4A3 human anti-tau antibody in mice.
ELISA
Figure 3 30 mg/kg NI-105.4E4 or NI-105.4A3 human anti-tau antibody was applied to the human IgG level in mouse retroperitoneal brain homogenate.
ELISA
Figure 4 ELISA measurement of NI-105.40E8 hIgG1 and NI-105.40E8 (R104W) hIgG1.
FuncS
Figure 5 Pathological aggregation of Tau protein in vivo and in brains of AD and tauopathies transgenic mice.
FuncS
Figure 6 Penetration of NI-105.6C5 or NI-105.6E3 anti-tau antibody in the brain of TauP301L mice.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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